Inhibitory and Inducing Effects of Astaxanthin on CYP
10.1625/jcam.12.51
- VernacularTitle:アスタキサンチンの薬物代謝酵素 CYP に対する酵素阻害作用と酵素誘導作用の検討
- Author:
Hiroki TSUKAHARA
;
Tazuru KIKKAWA
;
Shinichi FUKUYAMA
;
Hoko KYO
;
Nobutaka SUZUKI
- Publication Type:Journal Article
- Keywords:
Astaxanthin;
CYP-inhibition;
CYP-induction
- From:Japanese Journal of Complementary and Alternative Medicine
2015;12(1):51-54
- CountryJapan
- Language:Japanese
-
Abstract:
This study was aimed to evaluate the inhibitory effect of astaxanthin on 7 types of CYP enzymes (CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) by using human liver microsomes and to evaluate the inducing effect of astaxanthin on 3 types of CYP (CYP1A2, CYP2B6 and CYP3A4) by using cryopreserved human hepatocytes.Resuts indicated that astaxanthin does not inhibit CYP enzymes within the normal doses and astaxanthin does not induce CYP enzymes within the normal doses.
