Effect of the Deep Sea Shark-liver Oil Component Food on Secretion Type Immunoglobulin A Density of Saliva in the Normal Man and Woman Adult
10.1625/jcam.12.45
- VernacularTitle:健常男女成人における唾液の分泌型免疫グロブリン A 濃度に対する深海鮫肝油含有食品の効果
- Author:
Naobumi HAMADATE
;
Yoshiyuki MATSUMOTO
;
Mami SHIKURA
;
Chiemi MIZUKAMI
;
Kayoko SETO
;
Tetsuro YAMAMOTO
;
Hideyo YAMAGUCHI
;
Muneaki IIZUKA
;
Etsushi YAMAMOTO
;
Sumio KONDO
;
Kazunaga YAZAWA
- Publication Type:Journal Article
- Keywords:
Shark liver oil (SLO);
Immune system;
Secretory immunoglobulin A (s-IgA);
Saliva
- From:Japanese Journal of Complementary and Alternative Medicine
2015;12(1):45-49
- CountryJapan
- Language:Japanese
-
Abstract:
Secretory immunoglobulin A (s-IgA) in saliva constitutes the first-line barrier to the entry of pathogens into the body, implying its critical role in mucosal immunity.To examine the effect of a shark liver oil (SLO)-containing diet on salivary s-IgA concentration in healthy male and female adults, 42 subjects were assigned to either placebo or 6 weeks of a 2,400 mg SLO-containing diet (1,500 mg as SLO) and assessed in a randomized, double-blind, placebo-controlled, parallel group trial.Salivary s-IgA concentration significantly increased at week 6 in the SLO group (P = 0.033), but not in the placebo group.Moreover, there was a significant difference between groups in the magnitude of change from baseline to week 6.No intervention-related adverse event or abnormal changes of laboratory test parameters were observed throughout the study period.In conclusion, an SLO-containing diet increases salivary s-IgA in healthy adults.
