The Serum Lipid Lowering Effect of Rugosa Rose Petal Extract Rich in Polyphenols in Adults with High Serum Triglyceride
10.1625/jcam.12.29
- VernacularTitle:血清トリグリセライド高値の成人におけるポリフェノールを豊富に含むハマナス花弁抽出物の血清脂質低減効果
- Author:
Takashi YAMAGISHI
;
Keiji TAKANO
;
Sumio KONDO
- Publication Type:Journal Article
- Keywords:
Rosa rugosa polyphenol;
serum triglyceride;
serum cholesterol
- From:Japanese Journal of Complementary and Alternative Medicine
2015;12(1):29-35
- CountryJapan
- Language:Japanese
-
Abstract:
Objective: Hypertriglyceridemia or elevated serum triglyceride (TG) is a leading risk factor for developing atherosclerotic cardiovascular diseases.This clinical study was designed to test the potential of polyphenol-rich extract from Rosa rugosa petals (PE) for improving hypertriglyceridemia and other types of dyslipidemia. Methods: An open-label clinical study was conducted on 19 male and female adult subjects with elevated serum TG (120–399 mg/dL), who were intervened the study diet containing (in a daily dose) 200 mg of PE once daily for sss4 weeks.The serum levels of TG and cholesterols were measured at baseline and week-4.The efficacy was evaluated by comparing the measurements at these two timepoints. Results: A significant decrease (P < 0.05) in serum TG, as well as in serum total cholesterol and non HDL-cholesterol, and a marginally significant decrease (P = 0.070) in serum LDL-cholesterol were observed, while serum HDL-cholesterol was virtually not changed.The study diet was well tolerated without any untoward side effect. Conclusions: The PE-containing diet appears to have benefits in improving hypertriglyceridemia and hypercholesterolemia.
