Food and Drug Interactions: Effect of Acanthopanax senticosus Harms on CYP3A4 and CYP2C9 Activities (Part 3)
10.1625/jcam.11.17
- VernacularTitle:食―薬間相互作用：薬物代謝酵素 (CYP3A4, CYP2C9) 活性に対するエゾウコギの影響（第 3 報）
- Author:
Tsunehisa TAKAHASHI
;
Masaki IGARASHI
;
Takashi SATOH
;
Kazuhiro WATANABE
- Publication Type:Journal Article
- Keywords:
Acanthopanax senticosus Harms;
CYP3A4;
CYP2C9;
food and drug interaction;
pharmacokinetics
- From:Japanese Journal of Complementary and Alternative Medicine
2014;11(1):17-24
- CountryJapan
- Language:Japanese
-
Abstract:
Objective: By using human liver microsomes (HLM), we analyzed the effects of 14 known components of A.senticosus Harms on the activities of CYP2C9 and CYP3A4.
Methods and Results: Sesamin and quercetin inhibited both enzyme activities, whereas quercitrin strongly inhibited CYP3A4 activity. The 50% inhibitory concentrations (IC50s) of sesamin and quercetin on CYP2C9 activity were approximately 124- and 59-fold higher and the IC50s of sesamin, quercetin, and quercitrin on CYP3A4 activity were approximately 427-, 135-, and 22-fold higher than that of A. senticosus Harms extract (ASE), respectively. All these components inhibited both CYP3A4 and CYP2C9 in a non-competitive manner. However, these components are present in small amounts in ASE.
Conclusion: Therefore, the food-drug interactions caused by A. senticosus Harms are presumed to be due to the additive or synergistic interaction of these components or the other existing components, including their metabolites.
