Inhibitory Effect of Eucommia Bark on Tumour Formation in a Mouse Model of Two-Stage Skin Carcinogenesis
10.1625/jcam.10.117
- VernacularTitle:杜仲樹皮のマウス二段階皮膚発癌実験における腫瘍発現の抑制効果
- Author:
Ken YASUKAWA
- Publication Type:Journal Article
- Keywords:
Eucommia bark;
cancer prevention;
two-stage carcinogenesis
- From:Japanese Journal of Complementary and Alternative Medicine
2013;10(2):117-121
- CountryJapan
- Language:Japanese
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Abstract:
Cancer prevention is an important issue in the field of public health. In Oriental countries, Eucommia bark (the bark of Eucommia ulmoides) is used in tonics and anti-hypertensive medicines. Eucommia bark has inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. We demonstrated that at a dose of 1 mg/mouse, a methanol extract of Eucommia bark markedly inhibited the tumour-promoting activity of TPA in mice with skin tumour formation following initiation with 7,12-dimethylbenz[a]anthracene (DMBA). These results suggest the potential use of Eucommia bark in cancer prevention.
