Two Cases of Vasospastic Angina Poorly Controlled with Western Medicine Successfully Treated with a Combination of Traditional Shigyakusan and Keishibukuryogan Japanese Herbals
10.3937/kampomed.65.287
- VernacularTitle:西洋薬による症状コントロール困難な冠攣縮性狭心症に対して四逆散と桂枝茯苓丸の併用が有効であった2症例
- Author:
Taketoshi YAMAZAKI
;
Takashi MINE
;
Yasuyo HIJIKATA
- Publication Type:Journal Article
- Keywords:
vasospastic angina;
shigyakusan;
keishibukuryogan
- From:Kampo Medicine
2014;65(4):287-292
- CountryJapan
- Language:Japanese
-
Abstract:
Vasospastic angina (VSA) is a condition in which a relatively large coronary artery transiently exhibits abnormal vasoconstriction. Although an angina attack by VSA can usually be controlled with nitrates and calcium channel blockers (CCB), there are some patients whose VSA cannot be controlled even by combinations of these drugs. We report here two cases of VSA successfully treated with a combination of the traditional Japanese herbal (Kampo) medicines shigyakusan and keishibukuryogan. Case 1 was a 73-year-old male with chest discomfort during effort and at rest. A 24-h Holter monitoring showed a short period of marked ST segment elevation associated with his chest pain. Although nitrates and a CCB were administered, his symptoms persisted. We then prescribed shigyakusan and keishibukuryogan, and his chest pain improved. Case 2 was a 58-year-old male with chest discomfort at rest. Acetylcholine-provoked coronary spasm was observed. Although he was prescribed nitrates and a CCB, these medicines were not effective. After we prescribed shigyakusan and keishibukuryogan, his chest pain improved. The results experienced in these two cases suggest that shigyakusan and keishibukuryogan could be useful formulations for the treatment of VSA uncontrolled by conventional medical treatment.
