Effects of Rikkunshito on Cisplatin-induced Delay in Gastric Emptying in Rats
10.3937/kampomed.64.150
- VernacularTitle:シスプラチンによるラット胃排出低下に対する六君子湯の作用
- Author:
Yasuo MORIMOTO
;
Shimpei WATANABE
;
Seiwa MICHIHARA
;
Hisayoshi NORIMOTO
;
Keiko NAKAJIMA
;
Motoi HIURA
;
Toshiki OKUBO
- Publication Type:Journal Article
- Keywords:
rikkunshito;
cisplatin;
gastric emptying;
Atractylodis Rhizoma;
atractylenolide III
- From:Kampo Medicine
2013;64(3):150-159
- CountryJapan
- Language:Japanese
-
Abstract:
Rikkunshito is comprised of 8 crude drugs and is used for the treatment of gastrointestinal dysfunctions such as anorexia and heavy stomach feeling. These symptoms are often caused by delay in gastric emptying. Cisplatin is a representative cancer chemotherapeutic drug with severe adverse effects such as anorexia and nausea, that gives rise to a delay in gastric emptying. However, it is still unknown whether rikkunshito has effects on improving the delayed gastric emptying induced by cisplatin. In the present study, we examined the effects of rikkunshito (an Atractylodis rhizoma-containing formula) on cisplatin-induced delay in gastric emptying in the rat. Rikkunshito improved this. Among the crude drugs that comprise rikkunshito, Atractylodis rhizoma, Ginseng radix, Poria and Aurantii nobilis pericarpium individually improved the delay in gastric emptying, suggesting that they all contribute to the action of rikkunshito. Moreover, the effects of these 4 crude drugs in combinations were also examined, and as a result, tended to be stronger when Atractylodis rhizoma was included. On the other hand, when Atractylodis rhizoma was excluded from rikkunshito, the effects were weaker. Meanwhile, atractylenolide III, a specific chemical constituent of Atractylodis rhizoma, improved delay in gastric emptying in a manner similar to that of rikkunshito with Atractylodis rhizoma. These results, taken together, suggest that Atractylodis rhizoma likely contributes greatly to the improving effect of rikkunshito on cisplatin-induced delay in gastric emptying.
