Clinical Analysis of Cases with Drug-induced Liver Injury for Kampo Medicine
10.3937/kampomed.61.828
- VernacularTitle:漢方薬による薬物性肝障害の症例検討
- Author:
Yukari GONO
;
Hiroshi ODAGUCHI
;
Tomoyuki HAYASAKI
;
Kunihiko SUZUKI
;
Tetsuro OIKAWA
;
Akihiko MURANUSHI
;
Tohru AKAHOSHI
;
Toshihiko HANAWA
- Publication Type:Journal Article
- Keywords:
drug-induced liver injury;
Ogon;
DLST;
hepatocellular injury type;
early detection
- From:Kampo Medicine
2010;61(6):828-833
- CountryJapan
- Language:Japanese
-
Abstract:
We analyzed the clinical features of 21 cases with drug-induced liver injury due to Kampo medicines between the years 2000 and 2009 in our institute. The mean age in these cases was 55.2 ± 13.4 years. Five of the cases were men, and 16 were women. In 17 of the 21 cases, drug-induced liver injury had occurred within 3 months after beginning Kampo medicines. There were no subjective symptoms in 11 cases. Nine cases of both hepatocellular injury, and of mixed-type injury were seen. Causative Kampo medicines included an Ogon (Scutellariae Radix) component in 19 cases. A drug-induced lymphocyte stimulation test (DLST) was performed in 5 cases. The test was positive for Kampo medicines in only one of the 5 cases. Liver injury improved or normalized in 18 cases (85.7%) after discontinuing causative Kampo medicines. In another 2 cases, liver injury normalized after changing a Kampo medicine to the same prescription without Ogon. These results suggest that even if patients complain of no symptoms we must perform blood tests to check liver function within 3 months of prescribing Kampo medicines, especially those including Ogon, to facilitate early diagnosis of drug-induced liver injury.
