Four cases in which octreotide treatment relieved symptoms of gastrointestinal bleeding in end―stage cancer patients
10.2512/jspm.9.523
- VernacularTitle:終末期がん患者における消化管出血において，オクトレオチド投与が症状緩和に有効であったと考えられた4症例
- Author:
Naoko Kudo
;
Takashi Maeda
;
Kozue Suzuki
;
You Tei
;
Keiko Tanaka
- Publication Type:Journal Article
- Keywords:
octreotide;
gastrointestinal hemorrhage;
palliative care;
terminally ill;
neoplasms
- From:Palliative Care Research
2014;9(4):523-527
- CountryJapan
- Language:Japanese
-
Abstract:
Background：Although octreotide is effective in the relief of symptoms of gastrointestinal obstruction, it is also effective for gastrointestinal bleeding. It has been reported that octreotide reduced the splanchnic blood flow, and reduced the bleeding from esophageal varices, peptic ulcer and the tumor of gastrointestinal tract. We experienced four cases of end―stage cancer patients admitted to a palliative care unit whose symptoms of gastrointestinal bleeding were alleviated by octreotide（300μg／day）. Case：Case 1；A 75―year―old woman with gastric cancer developed melena and received octreotide. After octreotide was discontinued, melena and hematemesis recurred. Octreotide was restarted subsequently, and hematemesis resolved. Case 2；An 87―year―old woman with gastric cancer received octreotide for increase of bloody drainage from a stomach tube. She had epigastric pain and emotional distress from the blood. These symptoms were alleviated following the administration of octreotide. Cases 3 and 4；A 76―year―old man with gastric cancer and a 62―year―old man with bile duct cancer received octreotide for massive vomiting of blood. After the administration of octreotide, there was no reoccurrence of hematemesis in both patients. Conclusion：Octreotide may alleviate symptoms of gastrointestinal bleeding in end―stage cancer patients.
