Effects of habitual exercise and diet restriction on the hepatic fat accumulation in Zucker fatty rats
10.7600/jspfsm.63.223
- VernacularTitle:Zucker肥満ラットの肝脂肪蓄積の抑制に対する運動習慣と食餌制限の効果
- Author:
Yuka Kurosaka
;
Hiromi Kitamura
;
Hideki Yamauchi
;
Yoko Shiroya
;
Kumiko Minato
- Publication Type:Journal Article
- Keywords:
voluntary exercise;
restricted diet;
hepatic fat accumulation;
obesity;
Zucker fatty rat
- From:Japanese Journal of Physical Fitness and Sports Medicine
2014;63(1):223-229
- CountryJapan
- Language:English
-
Abstract:
We investigated the effects of habitual exercise and diet restriction on the hepatic fat accumulation in Zucker fatty rats. Male 6-week-old Zucker fatty rats were divided into obese (Ob), diet restriction (DR), and diet restriction + exercise (DR + Ex) groups. Male Zucker lean rats (L) were used as a control group. The rats in the L and Ob groups were maintained on ad libitum diets. The rats in the DR and DR + Ex groups were fed a 30% restricted diet. The rats in the DR + Ex group exercised voluntarily on a wheel ergometer. After 6 weeks of intervention, the serum free fatty acid and leptin levels in the Ob group were significantly higher than those in the L group. In the Ob group, the hepatic triglyceride content was higher than that in the L group and hepatocyte fat infiltration was observed on haematoxylin and eosin staining. These changes were suppressed by DR + Ex, but not by the DR intervention. These results suggest that habitual exercise inhibits fat accumulation in the liver of Zucker fatty rats.
