Rehabilitation for Crow-Fukase Syndrome Treated by High-Dose Chemotherapy with Autologous Peripheral Blood Stem Cell Transplantation : A Case Report
10.2490/jjrmc.50.922
- VernacularTitle:自己末梢血幹細胞移植を伴う大量化学療法によって治療されたCrow-Fukase症候群の長期的リハビリテーションの経過
- Author:
Akiko HISHINUMA
;
Mitsuru MAJIMA
;
Kyoko MAEDA
;
Hitoshi KURABAYASHI
- Publication Type:Journal Article
- Keywords:
Crow-Fukase syndrome;
autologous peripheral blood stem cell transplantation;
rehabilitation;
long-term prognosis
- From:The Japanese Journal of Rehabilitation Medicine
2013;50(11):922-926
- CountryJapan
- Language:Japanese
-
Abstract:
Crow-Fukase syndrome is diagnosed by the presence of polyneuropathy in conjunction with several other characteristic generalized symptoms, including organomegaly, endocrinopathy, M protein, and skin changes (POEMS syndrome). Rehabilitation is very important for patients with Crow-Fukase syndrome because progressive polyneuropathy reduces a patient's muscle strength. We report a case of long-term rehabilitation after high-dose chemotherapy with autologous peripheral blood stem cell transplantation. After transplantation, neurologic improvement began, and following rehabilitation therapy, the patient's proximal lower extremity muscle strength recovered to an almost normal level. At 2 months after transplantation, the patient could walk again using a cane and an ankle-foot orthosis. At six and a half years after transplantation, the neuropathy was still improving and there was no recurrence of other symptoms. We suggest that rehabilitation combined with autologous peripheral blood stem cell transplantation for Crow-Fukase syndrome is very useful for improving the disuse condition and for recovering muscle strength.
