Autoimmune Hemolytic Anemia Associated with Primary Biliary Cirrhosis
- Author:
Fumio Omata
;
Shinkichi Sato
;
Yasuharu Tokuda
;
Osamu Takahashi
;
Tsuguya Fukui
- Publication Type:Journal Article
- Keywords:
Primary biliary cirrhosis;
Autoimmune hemolytic anemia;
Splenectomy;
Bezafibrate
- From:General Medicine
2008;9(2):65-70
- CountryJapan
- Language:English
-
Abstract:
ABSTRACT : Both primary biliary cirrhosis (PBC) and autoimmune hemolytic anemia (AIHA) are uncommon diseases. Immunological dysregulation is suggested as a causative factor for both diseases. We report a 77-year-old woman who suffered from warm type AIHA complicated by PBC. Her direct antiglobulin test was positive for IgG, and negative for C3. Both anti-mitochondrial antibody and its M2 component were detected. Both alkaline phosphatase (Alp) and IgM were elevated in the serum. She was initially treated with steroids for 8 months. Her steroids were discontinued when she underwent a laparoscopic splenectomy. Ursodeoxycholic acid was discontinued due to an allergic skin reaction. Her Alp improved with bezafibrate.
