Identifying factors to differentiate neoplastic fever from infection retrospectively among terminally ill cancer patients
10.2512/jspm.8.273
- VernacularTitle:後ろ向き研究による, ホスピス入院患者における腫瘍熱と感染症の鑑別に寄与する因子の同定
- Author:
Takuya Odagiri
;
Tatsuya Morita
;
Toshihiro Yamauchi
;
Kengo Imai
;
You Tei
;
Satoshi Inoue
- Publication Type:Journal Article
- Keywords:
neoplastic fever;
infection;
white blood cell count;
CRP;
leukocyte diffential
- From:Palliative Care Research
2013;8(2):273-279
- CountryJapan
- Language:Japanese
-
Abstract:
Purpose and Methods: Infection and neoplastic fever is one of the common complication in patients with advanced cancer. To develop a novel method to differentiate neoplastic fever from infection, we performed a retrospective study of hospitalized terminally ill cancer patients at Seirei Hospice from April 2009 to August 2011. Results: We identified a consecutive sample of 12 patients with neoplastic fever and 12 patients with infection as a control. We extracted demographic data, laboratory data, vital signs and symptoms from medical charts. We found significant differences in difference in C-reacive protein value between afebrile and febrile period (p＜0.001), difference of white blood cell count between afebrile and febrile period (p=0.0017), percentages in neutrophil counts (p=0.023), percentages in lymphocyte counts at base line (p=0.011) and the presence of delirium (p=0.012). Conclusion: These findings suggest that we might differentiate neoplastic fever from infection with common laboratory data and their longitudinal change.
