Alternative routes of administration in palliative medicine: availability of sublingual administration
10.2512/jspm.5.201
- VernacularTitle:緩和ケアにおける代替投与経路‐舌下投与の有用性
- Author:
Kyoko Sato
;
Takashi Ando
;
Tomohiro Nishi
;
Mayumi Karino
;
Hiroshi Ishiguro
;
Tadashi Miyamori
- Publication Type:Journal Article
- Keywords:
sublingual administration;
palliative medicine;
buprenorphine;
fentanyl;
midazolam
- From:Palliative Care Research
2010;5(1):201-205
- CountryJapan
- Language:Japanese
-
Abstract:
Purpose: Evaluation of the efficacy and safety of sublingual drug administration in palliative care patients lacking the ability to swallow as well as other drug administration routes. Methods: Buprenorphine, 0.1∼0.2mg/dose (n=15) and fentanyl, 0.05∼0.2mg/dose (n=26) were administered sublingually for cancer pain, and midazolam, 0.1mg/kg (n=16) for insomnia respectively. Results: The three drugs were all rapidly absorbed by the oral cavity and showed efficacy in about 90% of patients. No adverse events were observed other than drowsiness, nausea and over production of sputum in patients suffering from dysphagia. Conclusion: Sublingual administration is a viable alternative for maintaining the quality of life of patients not accessible through conventional administration routes in the palliative setting. Palliat Care Res 2010; 5(1): 201-205
