A case of severe constipation caused by morphine administration that bowel movement was well controlled by misoprostol
10.2512/jspm.3.301
- VernacularTitle:ミソプロストール投与により良好な排便が得られたモルヒネによる高度便秘の１例
- Author:
Hiroki Yoshioka
;
Yusuke Kawano
;
Fujiyo Fukuda
;
Hideki Ikari
;
Tadaomi Kunisaki
- Publication Type:Journal Article
- Keywords:
misoprostol;
morphine;
prostaglandin E1 derivative;
constipation;
laxative
- From:Palliative Care Research
2008;3(1):301-304
- CountryJapan
- Language:Japanese
-
Abstract:
Objective: We experienced a case with recurring constipation and diarrhea caused by morphine for relieving cancer pain, who were well managed with oral administration of misoprostol. Subject: The patient was a male in his 70s with recurrent bladder cancer following primary surgery, developed bone metastasis to right side pelvis and exhibited cancer-related pain. To alleviate the resting pain, he underwent radiotherapy and received a sustained preparation of morphine sulfate, that lead to difficulty in bowel movements (repeated constipation and diarrhea) and abdominal distension which was intractable with routine administration of laxatives. Misoprostol, a prostaglandin E1 derivatives, which was reported to have an ability to control the bowel movement was administered at a dose of 800μg/day, and the patient subsequently achieved the improvement of bowel dysfunction and resumed regular self-defecation. Discussion: Misoprostol do not only accelerate small intestine movement but also inhibits water and sodium absorption. In this case, it is suggested that the pharmacological properties of misoprostol enabled to improve bowel movement. We consider that misoprostol is useful as one of the medications for refractory constipation caused by opioid administration. Palliat Care Res 2008:3(1);301-304
