Effect of oral ketamine on neuropathic pain
10.2512/jspm.3.216
- VernacularTitle:神経障害性疼痛に対する内服薬としてのケタミンの有用性についての検討
- Author:
Tetsu Sato
;
Tomomi Kataoka
;
Michihiro Shino
;
Hisayoshi Nishizaki
;
Isamu Adachi
- Publication Type:Journal Article
- Keywords:
ketamine;
oral;
lemonade;
neuropathic pain;
adjuvant analgesics
- From:Palliative Care Research
2008;3(1):216-220
- CountryJapan
- Language:Japanese
-
Abstract:
Purpose: Ketamine is effective on neuropathic pain that is difficult to respond to opioids among cancer pains, due to its N-methyl-D-aspartate (NMDA) receptor antagonism action. The purpose of this study was to evaluate the effect of oral ketamine on neuropathic pain. Methods: We retrospectively investigated the dosage and the administration period of oral ketamine in 31 patients for one year from December 2004. Results: Pain-relief was achieved in 22 of 31 patients, the average of initial dose was 107.3mg/day and the average administration period was 63 days. Seven patients discontinued oral ketamine within 7 days because of nausea/ vomiting (4 patients) or drowsiness (3 patients). Two patients had no sufficient pain-relief. Conclusion: This experience suggests that oral ketamine is effective on the management of neuropathic pain. Palliat Care Res 2008; 3(1): 216-220
