Collagen Gel Droplet-Embedded Culture Drug Sensitivity Test (CD-DST) for a Leiomyosarcoma Originating in the Inferior Vena Cava
10.4326/jjcvs.42.124
- VernacularTitle:CD-DST 法を適用した下大静脈原発平滑筋肉腫の1例
- Author:
Nobuo Kondo
;
Masaki Yamamoto
;
Hideaki Nishimori
;
Takashi Fukutomi
;
Seiichiro Wariishi
;
Kazuki Kihara
;
Miwa Tashiro
;
Kazumasa Orihashi
- Publication Type:Journal Article
- Keywords:
leiomyosarcoma in the inferior Vena cava;
CD-DST;
reconstruction of inferior Vena cava;
anticancer drug sensitive test
- From:Japanese Journal of Cardiovascular Surgery
2013;42(2):124-127
- CountryJapan
- Language:Japanese
-
Abstract:
The collagen gel droplet-embedded culture drug sensitivity test (CD-DST) identifies effective anticancer drug using resected tumor specimen, enabling tailor-made chemotherapy for a rare tumor. We report a case of the patient with leiomyosarcoma originating in the inferior vena cava, to which CD-DST was applied. This application has not been previously reported to the best of our knowledge. A 61-year-old woman consulted a nearby hospital because of abdominal pain. Computed tomography revealed an inferior vena cava tumor. The tumor was resected with the inferior vena cava, which was reconstructed with a 16 mm ePTFE graft. The tumor was diagnosed as leiomyosarcoma histopathologically. CDDP, VP-16, ADR, and VDS were CD-DST showed the tumor to be sensitive. Her postoperative course has been good without recurrence of tumor for 6 months, and the results of CD-DST may be helpful for chemotherapy strategy in case of recurrence.
