Innervation of cerebral vessels and pathogenesis of migraine
10.3777/jjsam.60.23
- VernacularTitle:脳血管の神経支配と片頭痛の病態
- Author:
Norihiro SUZUKI
- Publication Type:Journal Article
- Keywords:
migraine;
trigeminal nerve;
aura;
pulsating headache;
cortical spread depression;
calcitonin gene-related peptide;
triptan;
gepant
- From:Journal of the Japan Society of Acupuncture and Moxibustion
2010;60(1):23-31
- CountryJapan
- Language:Japanese
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Abstract:
Although migraine is not life-threatened disease, its burden in migraineurs is enough severe to affect the productivity in the society around them. Triptans, the most effective agents for the pain in the migraine attacks, have been available since 2000 in Japan. After then, the strategy for migraine treatment has been drastically changed. It has also affected the concept for migraine pathogenesis. Migraine has been attributed to certain abnormality in the cerebral blood vessels per se. However, the trigeminal nerve endings around cerebral or dural vessels are considered to play the key role in the migraine attacks since appearance of the triptans (i.e., trigeminovascular theory). Moreover, recent researches imply many possibilities of the 'migraine generator(s)'in the central nervous system.
