A Case of Type 1 Diabetes Mellitus with Improvement of Insulin Reserve by Glibenclamide.
10.2185/jjrm.49.626
- VernacularTitle:ＳＵ剤にて一時的にインスリン分泌が改善された１型糖尿病の１例
- Author:
Tomio KAMETANI
;
Kiyomori HASHIZUME
;
Kazuhiko SHIBATA
;
Kuniyoshi SHIMIZU
;
Hideo KOSHIDA
;
Tateyuki HORIGAMI
- Publication Type:Journal Article
- From:Journal of the Japanese Association of Rural Medicine
2000;49(4):626-630
- CountryJapan
- Language:Japanese
-
Abstract:
A 62-year-old woman was adimitted to our hospital because of thirst and a body weight loss of 9kg. She had a history of vasospastic breast pang 5months before. The level of fasting plasma glucose was 320 mg/dl and the level of HbA1c was 13.0%. The autoantibody to glutamic acid decarboxylase was positive. The level of urine C-peptide was 28.6μg/day. She rejected insulin injections and was treated with glibenclamide. The level of urine C-peptide increased to 70.0μg/day. The disease was controlled with the levels of 6.0% of HbA1c. But her condition became uncontrollable gradually after 6 months and she was treated by insulin therapy.
Insulin secretion in type 1 diabetes mellitus was transiently improved by sulfony 1 urea. This suggests that not only the insulin secretion but also glucotoxicity plays an important role in early stage of type 1 diabetes mellitus.
