The Prevalence of Serum Candida Antigen in Maintenance Hemodialysis Patients.
10.2185/jjrm.49.132
- VernacularTitle:慢性血液透析患者におけるカンジタ抗原保有頻度
- Author:
Gen KURAMOCHI
- Publication Type:Journal Article
- Keywords:
immunocompromised host
- From:Journal of the Japanese Association of Rural Medicine
2000;49(2):132-136
- CountryJapan
- Language:Japanese
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Abstract:
Previously, we have reported that Candida strains were morefrequently detected in the oral cavity of hemodialysis patients, particularly long-term patients, than in that of the patients with chronic glomerulonephritis ans conservative chronic renal failure. In the present study, we conducted a screening test for the prevalence of serum Candida antigen in hemodialysis patients and determined Candida species in the oropharyngeal portion of those with serum Candida antigen. Serum Candida antigen was found in 18.75% of the hemodialysis paients in our renal unit. Furthermore, Candida strains were detected in the oropharyngeal portion in 75.0%of those with serum Candida antigen. The percentage was higher than that of hemodialysis patients without serum Candida antigen (50.0%). Candida species determined in the oropharyngeal portion of the hemodialysis patients with serum Candida antigen were C. albicans (66.7%), C. glabrata (55.6%), C. krusei (11.1%), and C. parapsilosis (11.1%). There were no significant differences in age, hemodialysis periods, and the serum values of the nutrional markers (serum total protein, albumin, transferrin, and total cholesterol) between the hemodialysis patients with serum Candida antigen and those without. Generally, it is well known that hemodialysis patients are theso-called immunocompromised host. Therefore, it is necessary to examine serum Candida antigen and to determine Candida species in the oropharyngeal portion, wherewas first possible portion of mycotic infection, beforehand so as to predict the occurrence of invasive Candidiasis
