Changes in Salivary Bacterial Flora with the Progress of Glomerular Disease.
10.2185/jjrm.48.132
- VernacularTitle:糸球体腎疾患の進行に伴う唾液常在細菌叢の推移
- Author:
Akiko KONDOH
;
Kazuko ISHIZUKA
;
Gen KURAMOCHI
- Publication Type:Journal Article
- From:Journal of the Japanese Association of Rural Medicine
1999;48(2):132-136
- CountryJapan
- Language:Japanese
-
Abstract:
IgA nephropathy is the commonest form of chronic glomerular disease. The clinical manifestation of this disorder suggests an association with upper respiratory tract infections. Recently it has been reported that Haemophilus parainfluenzae has a role in the etiology of IgA nephropathy. Therefore, the relationship between glomerular disease and oral bacterial flora has attracted attention. Also, it is demonstrated that H. parainfluenzae can bind to high-molecular weight salivary mucins in a selective manner in humans. The present study focused on the changes in salivary bacterial flora, particular H. parainfluenzae species, with the progress of glomerular disease in patients with chronic glomerulonephritis (CGN), and chronic renal failure (CRF), and patients receiving hemodialysis (HD). With the progress of glomerular disease, the prevalence of Micrococcus, H. parainfluenzae, and Bacillus decreased, and the prevalence of Candida and CNS increased. The decrease in the prevalence of H. parainfluenzae was most remarkable. Serum complement (C3, C4, and CH50) levels decreased significantly in CRF and HD patients compared with those in CGN patients. Serum IgA levels in patients with H. parainfluenzae did not differ significantly from those in patient without H. parainfluenzae in each stage of glomerular disease. In conclusion, salivary bacterial flora changes with the progress of glomerular disease. The overwhelming prevalence of H. parainfluenzae in the stage of CGN compared with the stages of CRF and HD, may support the hypothesis that H. parainfluenzae has a role in the etiology of chronic glomerulonephritis.
