Drug-induced Liver Injury by Tranilast.
10.2185/jjrm.48.111
- VernacularTitle:トラニラストによる肝障害について
- Author:
Yukihito MINATO
;
Shinkan YO
;
Koji HATTORI
;
Tatsuo SHIIGAI
- Publication Type:Journal Article
- From:Journal of the Japanese Association of Rural Medicine
1999;48(2):111-115
- CountryJapan
- Language:Japanese
-
Abstract:
Tranilast, an anti-allergic drug, was originally made in Japan, and is now being frequently used. Though ill effects of Tranilast in urology have been known widely, the adverse effect of Tranilast on liver function has been scarcely reported. Having experienced 7 cases of liver disease due to cholestasis by the drug, we summarized these cases and reported the characteristics of liver injury induced by the drug.
All the patients, who had took Tranilast orally and developed liver injury, first manifested hematuria and micturition pain, and then developed jaundice. Though the degree of liver injury was various depending on individuals, the clinical course turned better about 27 days after cessation of Tranilast.
