The Analysis and Clinical Usefulness of HPV DNA Chip Test in the Uterine Cervix.
- Author:
Joo hyeon JEONG
1
;
Hyun Yee CHO
;
Na Rae KIM
;
Dong Hae CHUNG
;
Sanghui PARK
;
Seung Yeon HA
Author Information
1. Department of Pathology, Graduate School of Medicine, Gachon University, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
Human papillomavirus;
Oligonucleotide array sequence analysis;
Cytology;
Cervix uteri
- MeSH:
Biopsy;
Cervix Uteri;
DNA;
Far East;
Female;
Genotype;
Humans;
Oligonucleotide Array Sequence Analysis;
Prevalence;
Uterine Cervical Neoplasms
- From:Korean Journal of Pathology
2010;44(1):77-82
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The genotypes of human papillomavirus (HPV) are important in carcinogenesis in uterine cervical cancer and may be different in geographic distribution. METHODS: In 2,086 women, we analyzed the prevalence of HPV and HPV genotypes in uterine cervix by HPV-DNA chip test (n = 2,086), cytology (PAP smear, n = 1997) and biopsy (n = 546). RESULTS: Of the 2,086 cases, 1,019 cases (48.8%) were HPV-positive and 1,067 cases (51.2%) were negative for HPV. Single infection occurred most commonly (72.1% of women). HPV genotypes in the high-risk and low-risk groups, respectively were HPV-16/-58/-18/-52/-53 and HPV-70/-6/-11. The detection rates of HPV-70 in subjects older than 50 years increased significantly (p < 0.05). Infection in high risk subjects was detected in high grade lesions compared with infection in low risk subjects (p < 0.05). CONCLUSIONS: HPV-16/-58/-18/-52/-53/-70/-6/-11 genotypes were common in the patient group similar to findings in East Asia. HPV-70 infection is predominant in those older than 40 years.
