Study on acute and subchronic toxicity of cisplatin synthesized in Vietnam on the hemopoietic system
- Author:
Tran Binh Duyen
- Publication Type:Journal Article
- Keywords:
Acute toxicity;
Subchronic toxicity;
Cisplatin;
Hemopoiectic system
- MeSH:
Cisplatin;
Cisplatin/toxicity
- From:Pharmaceutical Journal
2005;0(5):16-19
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Experimentation of using Cisplatin produced by Vietnam with dose of LD50=26.00 (23.21-29.12) mg/kg on injection line on peritoneum of white house-mice was monitored for a week, and the 100% mice died. Before the death, the mice often had some kinds of epilepsy. It was proved that this medicine affected on central nervous system. In terms of semi-chronic toxicity, Cisplatin with dose of 0.2mg/kg/24 hours of intravenous injections 5 days per course, with dose of 0.3mg/kg/24 hours of intravenous injection in 5 days, using two courses after 10 days changed some indexes of hematology and microscopic findings of bone marrow. After 15 days to 30 days of discontinuous injection, injuries gradually recovered
