Fine Needle Aspiration Cytology of Langerhans Cell Histiocytosis of Mandible: A Case Report.
- Author:
Sang Ryung LEE
1
;
Jae Hee SUH
;
Hee Jung CHA
;
Young Min KIM
;
Hye Jeong CHOI
Author Information
1. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Histiocytosis;
Langerhans cell;
Mandible;
Cytology;
Child
- MeSH:
Biopsy;
Biopsy, Fine-Needle;
Child;
Histiocytes;
Histiocytosis;
Histiocytosis, Langerhans-Cell;
Humans;
Immunohistochemistry;
Langerhans Cells;
Mandible;
S100 Proteins
- From:Korean Journal of Pathology
2010;44(1):106-109
- CountryRepublic of Korea
- Language:English
-
Abstract:
We present a case of mandibular involvement with Langerhans cell histiocytosis (LCH), diagnosed by ultrasound-guided aspiration and subsequently confirmed by incisional biopsy and immunohistochemistry in an eight-year-old boy. The cytologic findings included the presence of characteristic Langerhans cells of both mononucleate and multinucleate form. Diagnostic confirmation was obtained by immunopositivity for S-100 protein and CD1a of Langerhans histiocytes on paraffin-embedded sections obtained during incisional biopsy of the right mandibular area. By reporting a case of childhood LCH, we correlate the cytologic findings with histologic features and discuss the role of aspiration cytologic diagnosis in such a rare and cytomorphologically characteristic case.
