Chronic toxic ellects of herbicide paraquat on rats.
10.2185/jjrm.39.71
- VernacularTitle:除草剤パラコートのラットへの慢性影響
- Author:
Shinji ASANUMA
;
Kiichiro SASAKI
;
Eisuke NAITOH
;
Kazuo KUROSAWA
;
Shousui MATSUSIMA
;
Mitsuru ANDO
;
Kenji TAMURA
;
Shouji YAMAMOTO
;
Ichisuke KAWAHARA
- Publication Type:Journal Article
- From:Journal of the Japanese Association of Rural Medicine
1990;39(2):71-76
- CountryJapan
- Language:Japanese
-
Abstract:
Paraquat is one the most popular herbicides in agriculture in Japan. To study the chronic toxicological effects of paraquat on animals, rats were fed a paraquat-containing diet for 1 year and 2 months (1, 5, 25mg/kg of body weight/day). Paraquat administration induced serious histochemical changes in various organs, such as the lung, heart, kidney and liver in rast. Pulmonary fibrosis occurred in the group of rats given 1mg paraquat/kg of body weight/day in diet.
The alkaline phosphatase activity and creatinine content in the blood serum significantly increased. The concentrations of cholesterol, triglyceride and phospholipid in the serum decreased significantly.
A significant increase of lipid peroxidation was observed in the brain, kidney and liver.
