Do hemodialysis and hemoperfusion contribute to the improvement of the motality in paraquat poisoning?

VernacularTitle:血液潅流や血液透析はパラコート中毒の予後を改善しているのか
Author: Shigehito Sato
Publication Type:Journal Article
From:Journal of the Japanese Association of Rural Medicine 1987;36(1):39-43
CountryJapan
Language:Japanese
Abstract: Striking discrepancy appears between:
the high performances of kidneys, HD and HP, in removing paraquat from the body
and the early established bad prognosis of the poisoning: the potentially lethal blood and urinary levels (which are good index of concentrations in lungs and other tissues) are very low
and the early established bad prognosis of the poisoning: the potentially lethal blood and urinary levels (which are good index of concentrations in lungs and other tissues) are very low
Do they actually increase the survival rate? Probably not. When they are started, potentially lethal concentrations have been already attained in highly vasculized tissues and in pneumocytes. These data suggest that the successful treatment of paraquat poisoning does not depend on the modification of the toxicokinetics of the weed-killer.