Effects of organophosphorus compound, cyanofenphos on the glucose metabolism in rats.
10.2185/jjrm.35.881
- VernacularTitle:有機燐剤，Ｃｙａｎｏｆｅｎｐｈｏｓのラット糖質代謝に及ぼす影響について
- Author:
Kazumitsu HIRAI
;
Takafumi TSUBOI
;
Motomi TORII
- Publication Type:Journal Article
- Keywords:
Cyanofenphos;
Glucose metabolism;
Delayed neurotoxicity;
Organophosphorus compound
- From:Journal of the Japanese Association of Rural Medicine
1987;35(5):881-886
- CountryJapan
- Language:Japanese
-
Abstract:
In order to observe the effect of organophosphorus compound, cyanofenphos (0-ethyl 0-4 -cyanophenyl phenylphosphonothioate) (CYP) on the glucose metabolism, 20 mg/kg of CYP was repeatedly administered per os to male Wistar rats, weighing approximately 150g. The supression of the serum and brain cholinesterase activity increased with times of administration, but muscular strength of extremities was not suppressed. The concentration of serum glucose, however, was enhanced in spite of the increase in the concentration of serum insulin. The mechanism of hyperglucosaemia resulted from the supression of the incorporation of glucose into cells in peripheral tissues without the activation of glycogen phosphorylase and suppression of glycogen synthetase activity. It was suggested that the suppression of the incorporation of gulcose into cells resulted from inhibition of insulin receptors or entry sites of glucose in cells by cyanofenphos.
The relation between disturbances of the glucose metabolism and the delayed neurotoxicity was discussed.
