Glycosylated hemoglobin assay among Japanese rural inhabitants and as an indicator of screening test for diabetes mellitus.
10.2185/jjrm.34.110
- VernacularTitle:農村地域住民におけるＨｂＡ１，ＨｂＡ１Ｃ検査成績 性・年令群別分布と糖尿病スクリーニング検査としての有用性
- Author:
Hideaki NAKAGAWA
;
Kenichiro TSUJIKAWA
;
Yoshiharu OKUMURA
;
Chieko KANAMORI
;
Shunichi KAWANO
;
Yoshie KITAMURA
;
Namiko NAKADA
- Publication Type:Journal Article
- From:Journal of the Japanese Association of Rural Medicine
1985;34(2):110-116
- CountryJapan
- Language:Japanese
-
Abstract:
The purpose of this study is to establish the normal physiological values of glycosylated hemoglobin (HbA1 and HbA1C) among Japanese rural inhabitants and to evaluate its potential as a screening tool for diabetes mellitus. Six hundred and seventy-five people aged 35-64 years (210 males and 465 females) were examined. Oral glucose tolerance tests were perfomed on 135 inhabitants of them by giving a 50-gm.
Frequency distributions of HbA1 and HbA1C fitted approximately to the log-normal distribution.
Geometric means and standard deviations in bracket were 7.95 (1.11)% for HbA1 in men, 8.13 (1.12)% for HbA1 in women, 5.17 (1.10)% for HbA1C in men and 5.16 (1.11)% for HbA1C in women
Group average values of HbA1 and HbA1C tended to increase with age in both men and women except a male group aged 60 years and over. There were no significant differences between mean values of glycosylated hemoglobin in men and those in women. HbA1 was positively correlated with age in women and negatively correlated with hemoglobin in both men and women. HbA1C was positively correlated with age in men and women, body mass index, systolic blood pressure and serum cholesterol in women, and negatively correlated with hemoglobin in men.
In order to evaluate glycosylated hemoglobin as a screening tool for the identification of unknown persons with diabetes, we calculated the sensitivity (the extents to which the participants who were found to have a diabetic OGTT also had an abnormal glycosylated hemoglobin) and specificity (the extents to which the participants who were not diabetic had normal glycosylated hemoglobin). The sensitivities for the person aged 59 years or under using HbA1 were 72.7-100% and the specificities 67.3-75.0 percent. Futhermore the sensitivities for the same aged person using HbA1C were 81.8-100% and the specificities 78.8-81.3 percent. The validities for both HbA1 and HbA1C were higher than those for glucosuria or blood glucose. But glycosylated hemoglobin was not useful as a screening tool for the person aged 60 years and over because of the low specificity.
