The Effect of Na2SO4NaHCO3Baths. (4). Skin histamine levels following the serial bathings under subcutaneous injection of Promethazine-HCl.
- VernacularTitle:硫酸ナトリウム・炭酸水素ナトリウム浴の効果 （第４報） 塩酸プロメタジン投与による家兎の皮膚ヒスタミン量の変化
- Author:
Yoshiaki KOMOTO
;
Shunichi HIRAI
;
Toshio FUJIWARA
;
Yoshimi KAWASAKI
- Publication Type:Journal Article
- Keywords:
Na2SO4·
NaHCO3 bathings;
skin histamin antihistamin;
allergic reaction
- From:The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine
1993;56(2):126-128
- CountryJapan
- Language:Japanese
-
Abstract:
Promethazine-HCl was used to suppress histamine production in the skin by Na2SO4·NaHCO3 bathing, confirming the previous data that the small amount of histamine released as a chemical mediator may have caused the warming effect, as observed in type I allergic reaction.
The skin histamine contents after serial bathings with Na2SO4·NaHCO3 under medication of Promethazine-HCl for 3 weeks were significantly reduced compared with that of tap water (p<0.05).
The skin histamine produced by physical stimulation of Na2SO4·NaHCO3 bathing was suppressed with H1-blocker (Promethazine), verifying that the warming effect with Na2SO4·NaHCO3 bathing was caused by histamine released as a chemical mediator, as observed in type I allergic reaction.
