Changes of atrial natriuretic polypeptide level in rats induced by artificial sodium sulfate bathing.
- VernacularTitle:人工ぼう硝泉浴によるラット心房性ナトリウム利尿ホルモン濃度の変化
- Author:
Hiroko KAWAMURA
;
Takashi YANAGA
;
Katsusuke NAGAI
;
Yoshimi KAWASAKI
- Publication Type:Journal Article
- Keywords:
atrial natriuretic polypeptide
- From:The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine
1989;52(2):92-96
- CountryJapan
- Language:Japanese
-
Abstract:
The effect of bathing with artificial sodium sulfate on changes in the systolic blood pressure and the level of atrial natriuretic polypeptide (ANP) in plasma or atrium of normotensive male rats was studied. The following results were obtained:
1) As a result of bathing for 20 minutes at a temperature of 37°C, the systolic blood pressure lowered and the plasma ANP level decreased. The blood pressure lowered most clearly after artificial sodium sulfate bathing at a prescribed concentration (p<0.5), while the plasma ANP level decreased significantly after plain water bathing (p<0.01).
2) The atrial ANP level showed no significant change. Presumably the reason was that the quantity of atrial ANP was so large that it was not affected by fluctuations in the peripheral ANP level.
3) The temperature and duration of bathing, the concentration of bath salts, and other factors might also influence the plasma ANP level.
These results suggest that the artificial sodium sulfate bathing lowers the blood pressure by preventing heat radiation from the skin and by delicate regulatory mechanisms on ANP secretion.
