Synthesis of bicucullin by method of forming cycle with Bischler-Napieralski
- Author:
Nguyen Dinh Luyen
- Publication Type:Journal Article
- Keywords:
Bicucullin;
Synthesis;
Forming cycle;
Bischler-Napieralski cyclization
- MeSH:
Bicuculline;
Pharmaceutical Preparations
- From:Pharmaceutical Journal
2003;0(6):6-9
- CountryViet Nam
- Language:Vietnamese
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Abstract:
Phthalideisoquinoline alcaloid norbicuculline have been synthesized by Bischler-Napieralski cyclization. The racemic norbicuculline were resolved into (+) and (-) forms. Methylation of (+ )norbicuculline provided (+)bicuculline. Researching bicucullin synthesis by the method of Bischler – napieralski shows that bicucullin is synthesized from Piperonal and Beta - (3,4 methylendioxy) – phenylethylamin by method of Bischler – napieralski. Isomers of ( ±) erythro and (±) threo norbicucullin are easily separated thank to nhờ sắc kí cột silicagel. Afterwards, optical isomers of (±) norbicucullin are also separated with high optical purity and good output. Methyl changed into (+) erythro norbicucullin is to gather (+) bicucullin gaining standards for biological experiments
