A Planned Prospective, Randomized, Placebo-Controlled Multicenter Trial Assessing the Effect of Helicobacter pylori Eradication on the Healing of Iatrogenic Ulcer after Endoscopic Resection of Gastric Neoplasm.
- Author:
Sang Gyun KIM
1
;
Ho June SONG
;
Il Ju CHOI
;
Joo Young CHO
;
Hwoon Yong JUNG
;
Bora KEUM
;
Jae Hee CHEON
;
Yong Chan LEE
;
Jae Gyu KIM
;
Sue K PARK
;
Byung Joo PARK
;
Hyun Chae JUNG
Author Information
1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. hyunchae@plaza.snu.ac.kr
- Publication Type:Multicenter Study ; Randomized Controlled Trial ; Original Article
- Keywords:
Helicobacter pylori;
Iatrogenic ulcer;
Endoscopic resection;
Eradication;
Medical Research Collaboration Center
- MeSH:
Adenoma;
Cooperative Behavior;
Follow-Up Studies;
Helicobacter;
Helicobacter pylori;
Humans;
Korea;
Prospective Studies;
Random Allocation;
Stomach Neoplasms;
Ulcer
- From:Gut and Liver
2010;4(4):514-517
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Helicobacter pylori eradication may facilitate the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. This study involved designing a randomized, double-blinded, placebo-controlled, multicenter trial, performed by the Korean College of Helicobacter and Upper Gastrointestinal Research and the Medical Research Collaboration Center, Seoul National University Hospital. METHODS: We intend to enroll up to 232 patients H.-pylori-positive patients who have gastric adenoma or early gastric cancer after endoscopic resection. The enrolled patients are being randomly allocated to the H.-pylori-eradication-plus-proton-pump-inhibitor group or the placebo-plus-proton-pump-inhibitor group based on their histology results and the size of the resected specimen. After random allocation, the iatrogenic ulcer size and stage are evaluated at 4- and 8-week follow-ups (with a window of +/-7 days). The primary end point is the healing rate of the ulcer by stage, and the secondary end point is the rate of ulcer size reduction, relief rate from ulcer-related symptoms, and adverse-event rates. RESULTS: More than 90% of the target subjects have already been enrolled into the study and are receiving ongoing periodic monitoring by the Medical Research Collaboration Center. CONCLUSIONS: Completion of the study should reveal whether H. pylori eradication can facilitate the healing of ulcer after endoscopic resection in Korea.
