Effects of tu-chung extract administrating on serum testosterone in hindlimb-suspended rats .
- VernacularTitle:尾部懸垂ラットヘの杜仲樹皮エキスの投与が血清テストステロン濃度に及ぼす影響
- Author:
GANG-JIAN QU
;
HIROSHI KANEKO
;
NAOYUKI EBINE
;
KAYOKO KITA
;
SEIJI TOMITA
;
TOSHIO MIKAMI
;
YOUSUKE TASAKI
;
AKIRA ITO
- Publication Type:Journal Article
- Keywords:
hindlimb-suspended rats;
Tu-Chung extract;
testosterone;
cAMP;
LH
- From:Japanese Journal of Physical Fitness and Sports Medicine
1999;48(4):501-507
- CountryJapan
- Language:Japanese
-
Abstract:
The purpose of this research was to study the effects of Tu-Chung extract (Eucommia ulmoides OLIV.) administration on serum testosterone and the possible mechanisms in hindlimb- suspended rats. 25 five-week old male Wistar rats were used. All rats were randomly divided into two groups : those treated with Tu-Chung extract (Tu-Chung G, n=suspended for 37 days in hindlimb. 1 mg/ml Tu-Chung extract was administered orally once daily at a dose of 1 ml/100 g body weight. Distilled water was administered in a similar way to the control group. The following results were observed :
1. Serum testosterone concentration in Tu-Chung G was significantly higher than in Cont. G (P<0.001) .
2. There was no significant difference between Tu-Chung G and Cont. G in serum LB concentrations.
3. The Testicular cAMP level in Tu-Chung G was significantly higher than that in Cont. G (P<0.01) .
4. 24-h urinary excretion of 17-ketosteroid in Tu-Chung G was significantly higher than that in Cont. G (P<0.001) .
5. There were no significant differences between the two groups in the weights per body weight of the kidneys, adrenal grand and testes. These results suggest that the adininstration of Tu-Chung extract inducing high serum testosterone concentrations in hindlimb-suspended rats might be due to enhanced testicular and adrenal functions, not pituitary.
