Acute exercise induces mitochondrial swelling of hepatocytes surrounding the terminal hepatic venule in rat liver acinus.
- VernacularTitle:急性運動によるラット肝小葉中心静脈周辺域実質細胞ミトコンドリアの膨化
- Author:
HIROMI YANO
;
SACHIFUMI KINOSHITA
;
LISA YANO
- Publication Type:Journal Article
- Keywords:
zone III;
zone I;
AKBR;
guanase
- From:Japanese Journal of Physical Fitness and Sports Medicine
1997;46(1):49-54
- CountryJapan
- Language:Japanese
-
Abstract:
In this study, we investigated the effect of acute exercise on the mitochondrial structure of hepatocytes surrounding the terminal hepatic venule (zone III) in the rat liver acinus. Male SD rats were assigned to a resting group (n=8) and to running groups ran on a motor-driven treadmill for 100 min (n = 8) or did continued running beyond 100 min until exhaustion (n = 5) . Plasma guanase activity was increased with duration time of exercise. The arterial ketone body rate (AKBR) increased during the 100 min of running, but the AKBR significantly diminished with exhaustive running as compared with that for 100 min of running. Although there was no change in the mitochondrial structure of hepatocytes in the perportal area (zone I) during exhaustion, remarkable swelling was observed in that in zone III.
These results suggest that acute running affects mitochondrial structures in zone III, and that this might be a hypoxia zone during exercise.
