Effect of physical training on the metabolism of serum and arterial cholesterol.
- VernacularTitle:血清および血管壁コレステロール代謝に及ぼす身体運動のトレーニング効果
- Author:
TOKUHIKO HIGASHI
;
NOBUKO TAKEI
;
SATOSHI SUZUKI
;
KOICHI HIROTA
;
TERUFUMI SAKAMOTO
- Publication Type:Journal Article
- Keywords:
physical training;
cholesterol;
serum;
artery;
LCAT
- From:Japanese Journal of Physical Fitness and Sports Medicine
1987;36(2):95-102
- CountryJapan
- Language:Japanese
-
Abstract:
The effect of a treadmill running program on the metabolism of cholesterol in serum and in arterial wall was studied in male Wistar rats, aged 7 weeks and weighing about 200 g- Rats were exercised on 6 days a week for 8 week, running 1, 000 m a day at 15 m/min. The trained rats gave the follwing evidence, as compared with the sedentary control animals:
1. Remarkably lower body weight
2. Significantly lower level of serum cholesterol-total, free, and LDL cholesterol
3. Elevated in vivo incorporation of 14C-mevalonate into serum cholesterol
4. Enhancement of lecithin-cholesterol acyltransferase activity in serum
5. Decrease in the amount of cholesterol in arterial wall cells
6. Increase in in vivo incorporation of 14C-mevalonate into arterial cholesterol.
The results indicate that the excersice promotes the turnover of cholesterol in serum and arterial wall, repressing the accumulation of choleterol ester in arterial wall cells, and a prophylactic effect of the physical training for arteriosclerotic diseases has been suggested.
