Effect of physical training on the metabolism of liver cholesterol.
- VernacularTitle:肝コレステロール代謝に及ぼす身体運動のトレーニング効果
- Author:
SATOSHI SUZUKI
;
NOBUKO TAKEI
;
TOKUHIKO HIGASHI
;
KOICHI HIROTA
;
TERUFUMI SAKAMOTO
- Publication Type:Journal Article
- Keywords:
physical training;
cholesterol;
rat liver;
HMG-CoA reductase;
cholesterol 7 α-hydroxylase
- From:Japanese Journal of Physical Fitness and Sports Medicine
1985;34(5):269-275
- CountryJapan
- Language:Japanese
-
Abstract:
The effect of a treadmill running program on the metabolism of cholesterol in liver was studied in male Wistar rats, aged 7 weeks and weighing about 200 g. Rats were exercised on 6 days a week for 8 weeks, running 1, 000 m a day at 15 m/min. The trained rats gave following evidence, as compared with the sedentary control animals:
1. Remarkable lower weight of body and liver
2. Significantly lower level of total and free cholesterol in liver
3. Elevated in vivo incorporation of14C-acetate and of14C-mevalonate into liver cholesterol
4. Enhanced incorporation of14C-mevalonate into cholesterol by liver slice
5. Increased activity of hydroxymethylglutaryl-coenzyme A reductase in liver
6. Increase in cholesterol 7 a-hydroxylase activity in liver
The results indicate that the exercise promotes the turnover of cholesterol in liver.
