Inhibitory Effects of Acupuncture, DPA and CMC and CMC on Sarcoma-180
10.3777/jjsam.31.122
- VernacularTitle:Sarcoma-180 に対する鍼と D-phenylalanine の抑制効果
- Author:
Norio Shimura
;
Chikako Nakamura
;
Yasuo Hirayama
;
Ayako Kato
- Publication Type:Journal Article
- Keywords:
Acupuncture;
D-phenulalanine;
Sarcoma-180;
integrity Homeostasis
- From:Journal of the Japan Society of Acupuncture and Moxibustion
1981;31(2):122-126
- CountryJapan
- Language:Japanese
-
Abstract:
We have been successful in preventing induced cavities in rats using acupuncture stimulation. In order to more profoundly understand one aspect of that preventative mechanism, we studied rises in natural antibody values and special antibody values using the Jerne method. In so doing, we proved that when D-phenylalanine (DPA) is administered 30 minutes proir to acupuncture stimulation the rise which occurrs in antibody counts with acupuncture is great and the duration of the period of increase is lengthened. Such reports about acupuncture effects on the living body are many. That acupuncture strengthens the stability of the living body is an unquestionable fact.
In an effort to study the preventative effects of acupuncture or acupuncture supplemented by DPA, we performed the following experiment. We planted Sarcoma-180, a homotransplantable tumor which often displays an immune resistant effect in mice and observed the immunity level rises produced by acupuncture and acupuncture supplemented by the administration DPA.
ICR mice (male, 3 weeks old) were divided into 5 groups: I-control grop, II-treatment with carboxymethyl cellulose sodium (CMC) III-treatment with CMC and DPA, IV-treatment with CMC and acupuncture, V-treatment with CMC, DPA and Acupuncture
Sarcoma-180 cells were administered to all the rats subcutanously in a ratio 106 cells/0.1ml after which cells were administered every 3rd day for a total of 4 times. DPA combined with 1% CMC was administered into the abdominal cavity in a concentration of 250mg/kg.
All of the mice were sacrificed on the 13th following the cancer transplant and the weight of the cancer, the liver and the spleen measured. Upon examinig for significant differences it was found that sigificant differences were indicated between Groups I and III, and I and V with a 1% danger rate, and I and IV with a 5% rate of danger. No signicant differnce was obseved between I and II.
It can be said that in the mice which received the Sarcoma-180 transplants macrophage funcctional insufficiency occured in a relatively early stage with decreased T lymph corpuscle functions occuring in the later stages. It can be assumed that in the process of interference with the functional in sufficiency, a preventative effect comes into play. In future studies we'd like to investingate the meaning of acupuncture for resistance to infection, etc.
