Association of Abdominal Obesity with Atherosclerosis in Type 2 Diabetes Mellitus (T2DM) in Korea.
10.3346/jkms.2008.23.5.781
- Author:
Minho CHO
1
;
Jong Suk PARK
;
Jisun NAM
;
Chul Sik KIM
;
Jae Hyun NAM
;
Hai Jin KIM
;
Chul Woo AHN
;
Bong Soo CHA
;
Sung Kil LIM
;
Kyung Rae KIM
;
Hyun Chul LEE
;
Kap Bum HUH
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. acw@yumc.yonsei.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Obesity;
Insulin Resistance;
Diabetes Mellitus Type 2;
Atherosclerosis
- MeSH:
Aged;
Atherosclerosis/complications;
Blood Pressure;
Coronary Vessels/pathology;
Diabetes Complications;
Diabetes Mellitus, Type 2/*genetics;
Female;
Humans;
Insulin Resistance;
Korea;
Male;
Middle Aged;
Obesity/*complications/*genetics;
Triglycerides/metabolism;
Tunica Intima/pathology;
Tunica Media/pathology
- From:Journal of Korean Medical Science
2008;23(5):781-788
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to investigate the relationship between obesity, insulin resistance and atherosclerosis in type 2 diabetes mellitus (T2DM) patients. Total 530 patients with T2DM were included. To evaluate the severity of atherosclerosis, we measured the coronary artery calcification (CAC) score, intima-media thickness (IMT) of the common carotid artery, and the ankle-brachial pressure index (ABPI). Subjects were classified according to body mass index (BMI), a marker of general obesity, and waist-to-hip ratio (WHR), a marker of regional obesity. The insulin sensitivity index (ISI) was measured by the short insulin tolerance test. All subjects were classified into four groups, according to BMI: the under-weight group, the normal-weight (NW) group, the over-weight (OW) group, and the obese (OB) group. WHR and systolic blood pressure, triglycerides (TG), HDL-cholesterol (HDLC), free fatty acids (FFA), fibrinogen, and fasting c-peptide levels were significantly different between BMI groups. TG, HDL-C, FFA, fibrinogen and ISI were significantly different between patients with and without abdominal obesity. In the OW group as well as in the NW group, carotid IMT, ABPI and CAC score were significantly different between patients with and without abdominal obesity. This study indicates that abdominal obesity was associated with atherosclerosis in T2DM patients.
