Effect of Delipidization on Binding of Hydrocortisone to Human Stratum Corneum.
- Author:
Dae Won GOO
;
Dong HOUH
;
Hyung Ok KIM
;
Chung Won KIM
- Publication Type:Original Article
- Keywords:
Binding;
Delipidizstion;
Hydrocortisone;
Stratum corneum
- MeSH:
Humans*;
Hydrocortisone*;
Skin
- From:Korean Journal of Dermatology
1989;27(4):347-351
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Skin lipids are a major constituent of the epidermal barrier, impermeable to a great extent to many chemicals. The barrier cspacity of the skin must be diminished by its delipidization through extract of the fatty material. The objectives of this study were to determine the degree that lipids and proteins contribute to the binding of straturn corneum in percutaneous penetration of hydrocortisone following skin delipidization. The binding capacity of C-hydrocortisone partitioned to powdered stratum corneum without delipidization in 10 human subjects was 1,554.34+/-357.48 dpm, and when delipidization, was 2,234.68+/-761.12 dpm. The partitioning rate was 0.38% in powdered stratum corneum without delipidization in 10 subjects, and when with ddipidization, was 0.55%. The result that the binding capacity of hydrocortisone to stratum corneum with delipidization increased more than without delipidization are statistically significant (p<0.05).
