Clinical and Histopathologic Study of Tsutsugamushi disease.
- Author:
Man Kyu PARK
;
Kee Suck SUH
;
Sang Tae KIM
- Publication Type:Original Article
- Keywords:
Clinical study;
Erythematous macule;
Eschar;
Histopathologic study;
Tsutsuga mushi disease
- MeSH:
Abdomen;
Age Distribution;
Busan;
Dermis;
Dilatation;
Edema;
Endothelial Cells;
Exocytosis;
Female;
Fever;
Headache;
Humans;
Incidence;
Korea;
Leg;
Male;
Myalgia;
Necrosis;
Scrub Typhus*;
Thorax
- From:Korean Journal of Dermatology
1989;27(4):412-420
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The clinical and histopathologic study of 26 cases with tsutsugamushi disease seen at the Department of Derrnatology, Kosin Medical Center, Pusan, Korea from October 1986 to December 1988 was performed. The results were summarized as follows : 1. Age distribution was from 12 to 73 years and male to female ratio was 1: 1.2 (1P, males 14 females). 2. The disease occurred from September to December in a year. The peak incidence was in October (61.5%). 3. Major clinical manifestations were as follows : Chill, fever and headache (100 %), maculopapular eruption (90.2%), eschar (88.5%) and myalgia (84.6%). 4. Eschars were distributed on the abdomen (34.8%), chest (30.4%), leg (7.4%) and ot.her sites. 5. Histopathologic findings of the erythernatous macules in 24 patients showed epiderrnal changes including exocytosis of rnononuclear cells (66.7%), liquefaction degeneration of basal cells (54.2%), spongiosis (33.3%) and epidermal cell necrosis (29.2%). Dermal changes revealed vascular dilatation and perivascular infiltration of rnononuclear cells (100%), extravasated RBC (50%), and edema of papillary dermis (45.8%). Epidermal changes around the eschar were liquefaction degeneration of basal cells (52.2%), spongiosis (43.5%) and exocytosis of mononuclear cells (30.4%). Dermal changes included vascular dilatation and perivascular mononuclear cell infiltration (100%), vessel wall necrosis (73.9%), ederna of papillary dermis (65.2%) and endothelial cell swelling (65.2%).
