Evaluate the influences of pentafluoropro pyloxydihydroartemisinin and mefloquine on some nervous functions of white rats
- Author:
Truong Van Nhu
- Publication Type:Journal Article
- Keywords:
Nervous functions
- MeSH:
Artemisinins;
Rats;
Animal Experimentation
- From:Pharmaceutical Journal
2005;347(3):12-16
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The study was carried out on 100 healthy rats, weight of 12020g which were divided into 10 groups. Raw materials: BB103 pure powder and mefloquine. Results: In rats received BB103 with doses of 50 mg/kg and mefloquine 50 mg/kg in 5 days, there were no significant changes on process of conditioned reflex, speed of reflex establishment was stable, response time and extinguishing time of reflex were similar to those of the control group (p>0.05). In rats received BB103 with doses of 100 mg/kg and mefloquine 100 mg/kg in 5 days, there were significant changes on speed of reflex establishment and response time (p<0.01-0.05). There were differences on speed of reflex establishment, speed of stable reflex in rats received BB103 and mefloquine (p<0.01-0.05)
