Inflammasomes in antiviral immunity: clues for influenza vaccine development.

Author: Tatsuya YAMAZAKI ¹ ; Takeshi ICHINOHE
Author Information

1. Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ichinohe@ims.u-tokyo.ac.jp
Publication Type:Review
Keywords: Orthomyxoviridae; Human NLRP3 protein; Metagenome; Dendritic cells
MeSH: Adaptive Immunity; Cell Death; Cytosol; Dendritic Cells; DNA; Inflammasomes*; Influenza Vaccines*; Influenza, Human*; Metagenome; Microbiota; Multiprotein Complexes; Orthomyxoviridae; RNA Viruses
From:Clinical and Experimental Vaccine Research 2014;3(1):5-11
CountryRepublic of Korea
Language:English
Abstract: Inflammasomes are cytosolic multiprotein complexes that sense microbial motifs or cellular stress and stimulate caspase-1-dependent cytokine secretion and cell death. Recently, it has become increasingly evident that both DNA and RNA viruses activate inflammasomes, which control innate and adaptive immune responses against viral infections. In addition, recent studies suggest that certain microbiota induce inflammasomes-dependent adaptive immunity against influenza virus infections. Here, we review recent advances in research into the role of inflammasomes in antiviral immunity.