A Case of Herpes Simplex Virus Type 2 Encephalitis of a Newborn Delivered by a Mother without Prenatal Screening.
10.14734/kjp.2014.25.3.195
- Author:
Eun Seob LEE
1
;
Joon Young KIM
;
Kon Hee LEE
;
Jung Won LEE
;
Yong Ju LEE
;
Yeon Joung OH
;
Ji Seok BANG
;
Tae Jung SUNG
Author Information
1. Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea. neosung@hallym.or.kr
- Publication Type:Case Report
- Keywords:
Encephalitis;
Herpes Simplex;
Newborn
- MeSH:
Acyclovir;
Brain;
Central Nervous System;
Early Diagnosis;
Emergency Service, Hospital;
Encephalitis*;
Fever;
Frontal Lobe;
Herpes Simplex;
Herpesvirus 2, Human*;
Humans;
Infant, Newborn*;
Mothers*;
Polymerase Chain Reaction;
Prenatal Diagnosis*;
Rare Diseases;
Seizures;
Simplexvirus;
Survivors
- From:Korean Journal of Perinatology
2014;25(3):195-201
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neonatal herpes simplex virus (HSV) encephalitis is a rare disease nowadays because of prenatal screening test and management. It shows progressive central nervous system manifestations affecting predominantly temporal and frontal lobes. Early diagnosis of HSV encephalitis is important since even with the early initiation of high-dose intravenous acyclovir therapy, it results in serious morbidity among survivors. A 14-day-old neonate with fever and poor oral intake was admitted via emergency department. The next day she had seizures and the brain was damaged with permanent sequelae despite of early administration of intravenous acyclovir on day 2 of admission. We report a serious case of HSV encephalitis diagnosed as type 2 HSV by polymerase chain reaction and culture of a newborn without proper prenatal screening test.
