Lycopene supplementation suppresses oxidative stress induced by a high fat diet in gerbils.
- Author:
Soo Kyong CHOI
1
;
Jung Sook SEO
Author Information
- Publication Type:Original Article
- Keywords: Lycopene; oxidative stress; antioxidant; Mongolian gerbils; high fat
- MeSH: Carotenoids; Catalase; Chronic Disease; Diet; Diet, High-Fat; Dietary Supplements; Erythrocytes; Gerbillinae; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Liver; Oxidative Stress; Plasma; Superoxide Dismutase
- From:Nutrition Research and Practice 2013;7(1):26-33
- CountryRepublic of Korea
- Language:English
- Abstract: The effect of lycopene supplementation on the antioxidant system was investigated by analyzing lipid peroxide levels, glutathione contents, and antioxidant enzyme activities in Mongolian gerbils fed a high fat diet. Gerbils were fed on each experimental diet for 6 weeks; normal diet (NC), normal diet with 0.05% lycopene (NL), high fat diet (HF), and a high fat diet with 0.05% lycopene (HFL). Dietary supplementation of lycopene increased hepatic lycopene level in gerbils fed a normal or high fat diet (P < 0.05). Liver and erythrocyte concentrations of lipid peroxide increased in gerbils fed a high fat diet, whereas lycopene supplementation decreased liver and erythrocyte concentrations of lipid peroxide (P < 0.05). Hepatic total glutathione content was higher in the NL group than that in the NC group (P < 0.05). Total antioxidant status in plasma increased following lycopene supplementation compared with that of the non-lycopene supplemented groups (P < 0.05). Hepatic catalase activity increased following dietary lycopene supplementation (P < 0.05). Superoxide dismutase activity in liver remained unchanged with lycopene supplementation, but erythrocyte superoxide dismutase activity increased in NL group compared with NC group (P < 0.05). Glutathione-S-transferase activity increased in the NL group compared to NC group (P < 0.05). Liver and erythrocyte glutathione peroxidase activity increased significantly in the NL group compared to that in the HF group (P < 0.05). Liver glutathione reductase activity was higher in the NL group than that in the NC group (P < 0.05). These results suggest that lycopene supplementation may be efficient for preventing chronic diseases induced by oxidative stress related to high fat diet.
