Clinical Findings in Chronic Renal Failure by Administering Wen-Pi-Tang (Onpito) Specially Compounded with Processed Rhubarb
10.3937/kampomed.57.787
- VernacularTitle:加熱大黄と湯脾湯を用いた慢性腎不全の治験
- Author:
Takashi OZAKI
- Publication Type:Journal Article
- Keywords:
catharsis;
chronic renal failure;
rhubarb;
sennoside
- From:Kampo Medicine
2006;57(6):787-791
- CountryJapan
- Language:Japanese
-
Abstract:
Rhubarb has been reported effective in patients with chronic renal failure, especially those patients with a high blood urea nitrogen (BUN) value. Rhubarb, however, is difficult to administer in large quantities because of its purging effect. Thus we prepared heated rhubarb, measured its sennoside A content using high performance liquid chromatography, and administered it to 2 patients.
Renal function of the first patient did not improve, following administration of extract derived from decocted rhubarb heated for 4 hours at 100°C.The extract's protective effect on renal function was considered lost by the boiling procedure. Dry-heated rhubarb was also prepared at 130°C for 4 minutes, and administered to the second patient. In this case, the extract's quantity could be increased up to 4.0g per day, and the patient's BUN value gradually decreased.
Onpito was later administered, because of increased BUN and creatinine values. Onpito was administered as a Ninjinto extract, Kakobushimatsu and rhubarb. And Onpito had a better protective effect on renal function in the second patient, than rhubarb alone.
In conclusion, we believe that dry-heated rhubarb can be effective for the improvement of nitric metabolism in patients with chronic renal failure, because of its low purging effect.
