Effects of Anti-Oketsu Drugs, Keishibukuryogan and Tokishakuyakusan on Platelet Aggregation in Normal Human Volunteer
10.3937/kampomed.56.561
- VernacularTitle:健常成人における桂枝ぶく苓丸と当帰しゃく薬散の血小板凝集に対する影響
- Author:
Shizuko TAKANO
;
Kozue SUZUKI
;
Akiko FUJISAKI
;
Miho FUTAGAMI
;
Fumihito ITO
;
Yuko ONO
;
Shinichi SAI
;
Makiho KATAKURA
;
Tomoko OISHI
;
Kenta SUGAYA
;
Seiichi ISHIBASHI
;
Yuuko KOBAYASHI
;
Michiko ABE
;
Yuhko DAIGAKU
;
Satomi MIYAMOTO
- Publication Type:Journal Article
- Keywords:
oketsu syndrome;
Keishibukuryogan;
platelet aggregation;
ADP;
collagen
- From:Kampo Medicine
2005;56(4):561-566
- CountryJapan
- Language:Japanese
-
Abstract:
Effects of anti-oketsu drug, Keishibukuryogan (Gui-zhi-fu-ling-wan) and Tokishakuyakusan (Dang-gui-shao-yao-san) in vivo and in vitro on platelet aggregation were investigated in normal volunteers.
Of 20 volunteers who were given Keishibukuryogan, there were 6, 3 and 11 subjects whose dose-response curves of collagen-induced aggregations were shifted to the right, to the left, or who had no shift, respectively. The control aggregations of these 20 people were in the same range. In ADP-induced aggregation, there were 5 curves shifted to the right. Their potencies in the control aggregation were higher than those of 9 subjects who were not affected by the drug. There were 6 curves shifted to the left, and their potencies were lower than those of the 9 unaffected subjects. Of 12 volunteers who were given Tokishakuyakusan, there were 2, 2 and 8 subjects whose dose-response curves in collagen-induced aggregation were shifted to the right, the left, or who had no shift respectively. With ADP-induced aggregation, there were 1, 1 and 10 subjects whose doseresponse curves were shifted likewise. In vitro, Keishibukuryogan caused inhibition of ADP-induced aggregation but not that of collagen-induced aggregation.
