Inhibitory Effect of Keishi-bukuryo-gan on CGRP-induced Elevation of Skin Temperature in GnRH Analogue-treated Male Rats.
10.3937/kampomed.54.791
- VernacularTitle:ＧｎＲＨアナログを処置した雄性ラットのＣＧＲＰ誘発皮膚温上昇に対する桂枝ぶく苓丸の抑制作用
- Author:
Mitsutoshi YUZURIHARA
;
Masamichi NOGUCHI
;
Yasushi IGARASHI
;
Yoshio KASE
;
Shuich TAKEDA
;
Masaki ABURADA
- Publication Type:Journal Article
- Keywords:
CGRP;
17β-estradiol;
GnRH analogue;
hot flushes;
Keishi-bukuryo-gan;
skin temperature;
testosterone
- From:Kampo Medicine
2003;54(4):791-795
- CountryJapan
- Language:Japanese
-
Abstract:
The gonadotropin-releasing hormone (GnRH) analogue (Leuplin/®1.0mg/kg, s. c.) induced not only a decrease in the serum concentration of testosterone but also potentiation of calcitonin gene-related peptide (CGRP: 10μg/kg, i. v.)-induced elevation of skin temperature in male rats. Keishi-bukuryo-gan (1, 000mg/kg, p. o.) and 17β-estradiol (0.010mg/kg, s. c.) significantly inhibited the elevation of skin temperature as well as teststerone (1.0mg/kg, s. c.) replacement. However, Keishi-bukuryo-gan and 17β-estradiol did not affect the low concentration of serum testosterone, although the hormone replacement of testosterone restored the plasma level. These results suggest that Keishi-bukuryo-gan, which does not have testosterone activity to serum, may be useful for the treatment of hot flushes due to testosterone deficiency after GnRH therapy in men with prostatic carcinoma, as well as 17β-estradiol.
