Effects of Choto-san(Diao-Teng-San) on Blood Pressure and Autonomic Nervous System in Spontaneously Hypertensive Rats of Progressive Hypertension.
10.3937/kampomed.53.343
- VernacularTitle:釣藤散の高血圧自然発症ラット（ＳＨＲ）進展期に対する血圧，自律神経系への影響
- Author:
Tomoyoshi YOKOSE
;
Toru HINO
;
Kazuaki KURODA
;
Yumi SAKURAI
;
Hisako YAMAMOTO
;
Tsuguto YOSHIZAWA
;
Tsunehide OKA
;
Katsuo KANMATSUSE
- Publication Type:Journal Article
- Keywords:
Choto-san;
SHR;
sympathetic nervous system
- From:Kampo Medicine
2002;53(4):343-349
- CountryJapan
- Language:Japanese
-
Abstract:
Choto-san was administered to 6-week-old spontaneously hypertensive rats (SHR) at the usual dose used for humans and at a 10-times higher dose, and its effects on blood pressure and the autonomic nervous system were examined. Significant blood pressure elevation was noted in the SHRs administered with the 10-fold dose, but no such changes were observed in the SHRs that were administered the usual human dose. Since the urinary levels of adrenaline and noradrenaline and the granulocyte count significantly increased in the 10-fold dose group, the elevation in blood pressure in this group appears to be attributable to stimulation of the sympathetic nervous system. Accelerated sympathetic nervous activity is noted in SHRs during the growing stage, and the excessively high dose of Choto-san probably further stimulated the sympathetic nervous activity.
