Effects of Toki-shigyaku-ka-goshuyu-syokyo-to for Neuropathic Pain in Rats.
10.3937/kampomed.53.205
- VernacularTitle:ラットのニューロパシックペインモデルに対する当帰四逆加呉しゅゆ生きょう湯の有効性について
- Author:
Keiko OKUDA
;
Yosuke USUI
;
Mio SHINOZAKI
;
Hirotoshi EGAWA
;
Shigeki YAMAGUCHI
- Publication Type:Journal Article
- Keywords:
neuropathic pain;
chronic constriction injury;
Toki-shigyaku-ka-goshuyu-syokyo-to;
thermal stimulation test;
measurements of body temperature;
rat
- From:Kampo Medicine
2002;53(3):205-209
- CountryJapan
- Language:Japanese
-
Abstract:
Objectives: We examined the effects of Toki-shigyaku-ka-goshuyu-shokyo-to on chronic constriction injury of the sciatic nerve as a neuropathic pain model in rats.
Methods: Sprague-Dawley rats were randomly divided into 3 groups: group 1, no constriction and no medication (n=8); group 2, constriction without medication (n=8); group 3, constriction with medication (n=8). On each group we performed thermal stimulation tests for pain measurement before the operation and 7 and 14 days after the operation. We also measured body temperature at the tympanum and the planta.
Results and conclusions: A significant increase of pain was observed at 7 and 14 days after constriction in group 2. Toki-shigyaku-ka-goshuyu-shokyo-to relieved their pain 14 days after constriction. Furthermore,
Toki-shigyaku-ka-goshuyu-shokyo-to warmed their feet significantly, while chronic constriction injury induced coldness in the constricted feet. We conclude that Toki-shigyaku-ka-goshuyu-shokyo-to relieves both pain and coldness in a neuropathic pain model.
